产品介绍 基因名： NLRP4 产品别名： CLR19.5； CT58； NALP4； PAN2； PYPAF4； RNH2； NLRP4； NLR family pyrin domain containing 4； NLR family pyrin domain containing 4； NACHT, LRR and PYD domains-containing protein 4； NACHT, leucine rich repeat and PYD containing 4； PAAD and NACHT-containing protein 2； PYRIN and NACHT-containing protein 2； PYRIN-containing APAF1-like protein 4； cancer/testis antigen 58； nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 4； ribonuclease inhibitor 2； 癌/睾丸抗原58； 背景信息： NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]. 标签：His-tag |
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