蛋白质/抗原/多肽 >> 重组蛋白
重组周期素依赖性激酶13(CDK13)蛋白
产品介绍 基因名： CDK13 产品别名： CDC2L； CDC2L5； CHDFIDD； CHED； hCDK13； CDK13； cyclin dependent kinase 13； cyclin dependent kinase 13； cyclin-dependent kinase 13； CDC2-related protein kinase 5； cell division cycle 2-like protein kinase 5； cell division protein kinase 13； cholinesterase-related cell division controller； 周期素依赖性激酶13(CDK13)； 细胞分裂周期2样蛋白激酶5； 背景信息： Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. Tissue specificity:Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma and glioblastoma tumors. 标签：His-tag |
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