产品介绍 基因名： GCNT1 产品别名： C2GNT； C2GNT-L； C2GNT1； C2GlcNAcT； G6NT； NACGT2； NAGCT2； GCNT1； glucosaminyl (N-acetyl) transferase 1； glucosaminyl (N-acetyl) transferase 1； beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase； beta-1,6-N-acetylglucosaminyltransferase； core 2 GnT； core 2 beta-1,6-N-acetylglucosaminyltransferase I； core 2 beta1,6 N-acetylglucosaminyltransferase-I； core 2 branching enzyme； core2-GlcNAc-transferase； glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase)； leukocyte type core 2 beta-1,6-N-acetylglucosaminyltransferase； GCNT1葡萄糖转移酶； 背景信息： GCNT1 is expressed in a variety of cell types, including lymphocytes and mucin-producing cells. Specifically, GCNT1 expression in leukocytes regulates the synthesis of core 2 O-glycans that carry sialyl-Lewis x (sLex) oligosaccharides, which confer high affinity binding to Selectins. Downregulation of Selectin ligand expression levels has been shown to inhibit tissue infiltration. Therefore, GCNT1 represents a potential drug target for the treatment of inflammatory disorders and other pathologies involving Selectins. 标签：His-tag |
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