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p400蛋白抗体
产品介绍 靶标: EP400 产品别名: CAGH32; P400; TNRC12; EP400; E1A binding protein p400; E1A binding protein p400; E1A-binding protein p400; CAG repeat protein 32; domino homolog; hDomino; hDomino(p400); p400 SWI2/SNF2-related protein; p400 kDa SWI2/SNF2-related protein; trinucleotide repeat containing 12; trinucleotide repeat-containing gene 12 protein; p400蛋白; 背景信息: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. 宿主:Rbt |
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